Bis(2-hydroxyethyl)(3-methoxy-4-nitrobenzyl)phosphonate → Bis(2-hydroxyethyl)(4-amino-3-methoxybenzyl)phosphonate

HRID 1947874ノート

反応式

HRID 1947874 の反応式
[OH:1][CH2:2][CH2:3][O:4][P:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[C:14]([O:21][CH3:22])[CH:13]=1)(=[O:10])[O:6][CH2:7][CH2:8][OH:9].[H][H]>CCO.[Pd]>[OH:9][CH2:8][CH2:7][O:6][P:5]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([O:21][CH3:22])[CH:13]=1)(=[O:10])[O:4][CH2:3][CH2:2][OH:1]

参加物

5

反応物 2

HCID 86654013Bis(2-hydroxyethyl)(3-methoxy-4-nitrobenzyl)phosphonate2 回HCID 178418361HCID 178418361、化合物

生成物 1

HCID 86654012Bis(2-hydroxyethyl)(4-amino-3-methoxybenzyl)phosphonate収率 82.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of bis(2-hydroxyethyl)(3-methoxy-4-nitrobenzyl)phosphonate (Compound 133B, 1.2 g, 3.58 mmol) and 5% Pd/C (0.2 g) in EtOH (80 mL) was hydrogenated under 50 psi hydrogen pressure at 40° C. for 6 h. The reaction mixture was filtered and the filtrate was concentrated to give the desired product (0.9 g, 82%).

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-fe4395e1679a4a13878ee71d2304b344
出典データセット
uspto-grants-2013_03
特許番号
US08399433B2

反応ノート

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