Trifluoroacetic acid → 7-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

HRID 1947889ノート

反応式

HRID 1947889 の反応式
C(OC([NH:8][C:9]1[C:17]2[C:16](=[O:18])[N:15]([CH3:19])[CH2:14][C:13]=2[C:12]([C:20]([OH:22])=[O:21])=[CH:11][CH:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:8][C:9]1[C:17]2[C:16](=[O:18])[N:15]([CH3:19])[CH2:14][C:13]=2[C:12]([C:20]([OH:22])=[O:21])=[CH:11][CH:10]=1

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 672564057-[(Tert-butoxycarbonyl)amino]-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

生成物 1

HCID 672542797-amino-2-methyl-1-oxo-2,3-dihydro-1H-isoindole-4-carboxylic acid

実験手順

The title compound was prepared by deprotecting Compound 116C with TFA. The crude product was taken on to the next step without purification.

後処理

  1. customThe crude product was taken on to the next step without purification

出典と根拠

ORDレコード
ord-b0aba7bb9d2343b3939ab5a3f0f58a1b
出典データセット
uspto-grants-2013_03
特許番号
US08399433B2

反応ノート

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