Methyl iodide → 1-(4-chlorobenzyl)-4-(2-methoxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one

HRID 1948270ノート

反応式

HRID 1948270 の反応式
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[C:10]([CH2:21][CH2:22][OH:23])=[CH:9][C:8]2=[O:24])=[CH:4][CH:3]=1.I[CH3:28]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[CH:10]([CH2:21][CH2:22][O:23][CH3:28])[CH2:9][C:8]2=[O:24])=[CH:25][CH:26]=1.[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[C:10]([CH2:21][CH2:22][O:23][CH3:28])=[CH:9][C:8]2=[O:24])=[CH:25][CH:26]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 693503681-(4-chlorobenzyl)-4-(2-hydroxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one

生成物 2

HCID 589669471-(4-chlorobenzyl)-4-(2-methoxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one収率 171.4%HCID 694427411-(4-Chlorobenzyl)-4-(2-methoxyethyl)-5-(4-methoxyphenyl)pyridin-2(4H)-one

実験手順

According to Scheme 30 Step 4: The title compound was prepared from 1-(4-chlorobenzyl)-4-(2-hydroxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one (1 eq, 0.14 mmol, 50 mg) and iodomethane (3 eq, 0.41 mmol, 58 mg) according to the procedure described for Example 34 Step 3. The product was further purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 5 g SiO2) using Et2O/pentane 90/10 to afford 1-(4-chlorobenzyl)-4-(2-methoxyethyl)-5-(4-methoxyphenyl)pyridin-2(1H)-one (0.12 mmol, 47 mg, 91%) as a colorless oil.

後処理

  1. customThe product was further purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 5 g SiO2)

出典と根拠

ORDレコード
ord-bd47c347013a405faf28101f1efaebf5
出典データセット
uspto-grants-2013_03
特許番号
US08399493B2

反応ノート

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