Thionyl Chloride → 2-(Chloromethyl)-1-fluoro-4-iodo-3-methylbenzene
反応式
[F:1][C:2]1[C:7]([CH2:8]O)=[C:6]([CH3:10])[C:5]([I:11])=[CH:4][CH:3]=1.S(Cl)([Cl:14])=O>C1C=CC=CC=1>[Cl:14][CH2:8][C:7]1[C:6]([CH3:10])=[C:5]([I:11])[CH:4]=[CH:3][C:2]=1[F:1]参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution of the product of Step C (4.01 g, 15.4 mmol) in anhydrous benzene (40 mL) was added dropwise thionyl chloride (3.7 g, 30.8 mmol). The mixture was stirred 80° C. overnight. The mixture was cooled to rt, washed with saturated aqueous sodium bicarbonate solution, water and brine, and dried over magnesium sulfate, and concentrated to dryness to give the title compound as a colorless oil.
後処理
- temperatureThe mixture was cooled to rt
- washwashed with saturated aqueous sodium bicarbonate solution, water and brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-4bf1d041511248fdbbe0683681c020c1
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399507B2
反応ノート
読み込み中…