Hydrochloric Acid → 3-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid

HRID 1951225ノート

反応式

HRID 1951225 の反応式
C[O:2][C:3](=[O:20])[CH:4](C(OCC)=O)[CH2:5][C:6]1[S:7][C:8]([NH:11][C:12]([NH2:14])=[S:13])=[N:9][N:10]=1.Cl>[OH-].[Na+]>[NH:11]([C:8]1[S:7][C:6]([CH2:5][CH2:4][C:3]([OH:20])=[O:2])=[N:10][N:9]=1)[C:12]([NH2:14])=[S:13]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86653060Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester

生成物 1

HCID 866062213-(5-Thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

Carbethoxy-3-(5-thioureido-[1,3,4]thiadiazol-2-yl)-propionic acid methyl ester (0.675 g, 2.91 mmol) is suspended in 2M NaOH (8 ml) and the reaction is stirred at reflux for 3.5 hours. When cool, the solution is acidified to pH 3 with 6M HCl and the titled compound is removed by filtration and dried.

後処理

  1. temperatureat reflux for 3.5 hours
  2. temperatureWhen cool
  3. customthe titled compound is removed by filtration
  4. customdried

出典と根拠

ORDレコード
ord-e963e179c2b34315ad0c3f3def9be1e2
出典データセット
uspto-grants-2013_03
特許番号
US08404684B2

反応ノート

読み込み中…