Hydrochloric Acid → 3-Bromo-4-(4-trifluoromethyl-benzyl)-4H-thieno[3,2-b]pyrrole

A mixture of 3 g of the product of Step 4 and 0.3 g of copper powder in 50 ml of quinoline was heated in oil bath at 140° C. for 4 h. The reaction mixture was cooled and acidified with 6 N HCl and then extracted with 150 ml of ether. The ether layer was washed with 200 ml of 2 N HCl, dried over Na2SO4, filtered, and concentrated to give 2.2 g of the title compound as a light brown solid.

1. temperatureThe reaction mixture was cooled
2. extractionextracted with 150 ml of ether
3. washThe ether layer was washed with 200 ml of 2 N HCl
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated

ORDレコード

ord-b65f395fb4f64c30bd70efb3bc786c11

出典データセット

uspto-grants-2013_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08404736B2