Chloroacetamide → HCID 23302056、化合物
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[CH2:8][CH:7]([NH2:14])[CH2:6]2.C(=O)(O)[O-].[Na+].Cl[CH2:21][C:22]([NH2:24])=[O:23]>C(O)C>[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[CH2:6][CH:7]([NH:14][CH2:21][C:22]([NH2:24])=[O:23])[CH2:8]2参加物
5
実験手順
5,6-Dimethoxy-2-indanylamine (0.024 moles, 4.6 g) and sodium bicarbonate (0.026 moles, 2.2 g) are added to a solution of chloroacetamide (0.024 moles, 2.2 g) in absolute ethanol (100 ml) and refluxed for 10 hours. The mixture is filtered at r.t. and the solution is evaporated to dryness. The resulting oil is chromatographed under medium pressure through silica gel (eluent: methylene chloride/methanol=90/10) Yield: 1.95 g (32.7%)--m.p.=135-138° C.
後処理
- temperaturerefluxed for 10 hours
- filtrationThe mixture is filtered at r.t.
- customthe solution is evaporated to dryness
- customThe resulting oil is chromatographed under medium pressure through silica gel (eluent: methylene chloride/methanol=90/10) Yield: 1.95 g (32.7%)
出典と根拠
- ORDレコード
- ord-fefa833ab59b44b6bcfbcf18620be3d7
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06114391
反応ノート
読み込み中…