Pyridine → N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine

HRID 1953200ノート

反応式

HRID 1953200 の反応式
[CH3:1][S:2][CH3:3].ClCl.[NH2:6][C:7]1[N:11]([CH3:12])[N:10]=[CH:9][C:8]=1[Br:13].N1C=CC=CC=1>ClCCl>[Br:13][C:8]1[CH:9]=[N:10][N:11]([CH3:12])[C:7]=1[N:6]=[S:2]([CH3:3])[CH3:1]

参加物

6

反応物 4

HCID 1049PyridineHCID 1068Dimethyl SulfideHCID 24526ChlorineHCID 6003514-Bromo-1-methyl-1H-pyrazol-5-amine

生成物 1

HCID 23303942N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 0.60 mL (8.2 mmol) of dimethyl sulfide in 30 mL of dichloromethane was cooled to -20° C. and 0.50 g (7.0 mmol) of chlorine was added through a sparge tube with cooling and stirring. Subsequently, 1.0 g (5.7 mmol) of 5-amino-4-bromo-1-methylpyrazole and then 1.0 g (12.7 mmol) of pyridine were added with cooling and stirring. A 2 mL aliquot of this mixture was removed and the light yellow solids present were collected by filtration and washed with deuteroacetonitrile.

後処理

  1. temperaturewith cooling
  2. temperaturewith cooling
  3. stirringstirring
  4. customA 2 mL aliquot of this mixture was removed
  5. filtrationthe light yellow solids present were collected by filtration
  6. washwashed with deuteroacetonitrile

出典と根拠

ORDレコード
ord-094fdb8f9ce14445bae27c56b49e48d2
出典データセット
uspto-grants-2000_09
特許番号
US06114580

反応ノート

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