Sodium Hydroxide → HCID 9825643、化合物
反応式
Cl.[C:2]1([S:8]([NH:11][C:12]2[CH:36]=[CH:35][C:15]3[N:16]([CH2:29][C:30]([O:32]CC)=[O:31])[C:17]([CH2:19][C:20]4[CH:28]=[CH:27][C:23]([C:24]([NH2:26])=[NH:25])=[CH:22][CH:21]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[C:2]1([S:8]([NH:11][C:12]2[CH:36]=[CH:35][C:15]3[N:16]([CH2:29][C:30]([OH:32])=[O:31])[C:17]([CH2:19][C:20]4[CH:28]=[CH:27][C:23]([C:24]([NH2:26])=[NH:25])=[CH:22][CH:21]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:10])=[O:9])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
反応条件
- 温度
- 40 °C
実験手順
200 mg (0.379 mmol) of 4-[(5-benzenesulphonylamino-1-ethoxycarbonylmethyl-1H-benzimidazol-2-yl)-methyl]-benzamidine-hydrochloride are dissolved in 10 ml ethanol and stirred at 40° C. for 90 minutes after the addition of 1 ml 2N sodium hydroxide solution. The solvent is distilled off, the residue diluted with 20 ml water and acidified with glacial acetic acid. The precipitated product is suction filtered and dried.