Ethanol → HCID 23298086、化合物

HRID 1953413ノート

反応式

HRID 1953413 の反応式
C(N[C:5]1[C:10](/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]([NH:19][C:20]3[C:25]([NH2:26])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:9][CH:8]=[CH:7][N:6]=1)(=O)C.[Cl-].[NH4+:28].[CH2:29]([OH:31])[CH3:30]>[Fe].O>[C:29]([NH:28][C:7]1[N:6]=[CH:5][C:10](/[CH:11]=[CH:12]/[C:13]2[CH:14]=[C:15]([NH:19][C:20]3[C:25]([NH2:26])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH:16]=[CH:17][CH:18]=2)=[CH:9][CH:8]=1)(=[O:31])[CH3:30]

参加物

6

反応物 3

HCID 702EthanolHCID 25517Ammonium ChlorideHCID 232980872-[3-[(E)-2-(2-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine

生成物 1

HCID 23298086HCID 23298086、化合物

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 962Water溶媒

実験手順

A mixture of 2-[3-[(E)-2-(2-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine (1.86 g), iron powder (1.39 g) and ammonium chloride (0.26 g), ethanol (20 ml) and water (6 ml) was stirred under reflux for an hour. The reaction was filtered, concentrated and extracted with chloroform. The extracts were washed with saturated sodium bicarbonate solution, dried and evaporated to afford 2-[3-[(E)-2-(6-acetamido-3-pyridyl)vinyl]phenylamino]-3-aminopyridine as dark purple crystals (1.59 g).

後処理

  1. temperatureunder reflux for an hour
  2. filtrationThe reaction was filtered
  3. concentrationconcentrated
  4. extractionextracted with chloroform
  5. washThe extracts were washed with saturated sodium bicarbonate solution
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-72f7a37a2ca0483ba7f2a2b1bb9946e1
出典データセット
uspto-grants-2000_09
特許番号
US06117875

反応ノート

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