Methyl iodide → methyl (2RS,3S)-3-amino-2-hydroxyheptanoate

HRID 1953441ノート

反応式

[NH2:1][C@@H:2]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:3]([OH:14])[C:4]([O:6][CH2:7]C1C=CC=CC=1)=[O:5].C(Br)C1C=CC=CC=1.CI>>[NH2:1][C@@H:2]([CH2:15][CH2:16][CH2:17][CH3:18])[CH:3]([OH:14])[C:4]([O:6][CH3:7])=[O:5]

参加物

反応物 3

HCID 6328Methyl iodide

HCID 7498Benzyl Bromide

HCID 56995658phenylmethyl (2RS,3S)-3-amino-2-hydroxyheptanoate

生成物 1

HCID 54272153methyl (2RS,3S)-3-amino-2-hydroxyheptanoate収率 91%

実験手順

The same reaction procedure for synthesizing of phenylmethyl (2RS,3S)-3-amino-2-hydroxyheptanoate as in Reference Example 17 was repeated except that benzyl bromide used in Reference Example 17 was replaced by 579 mg of methyl iodide, whereby 683 mg of the captioned methyl (2RS,3S)-3-amino-2-hydroxyheptanoate was obtained in a yield of 91%.

後処理

customThe same reaction procedure

出典と根拠

ORDレコード: ord-c5f9c186745040cf8ede17d73f1edc76
出典データセット: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06117870

反応ノート

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