Nitric Acid → HCID 178459885、化合物
反応式
[CH2:1]([O:4][C:5](=[O:33])[NH:6][C@@H:7]([C:15]([N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[C:22](=[O:32])[NH:23][CH2:24][C@H:25]1[CH2:30][CH2:29][C@H:28]([NH2:31])[CH2:27][CH2:26]1)=[O:16])[C:8]([S:11][CH:12]([CH3:14])[CH3:13])([CH3:10])[CH3:9])[CH2:2][CH3:3].[N+:34]([O-:37])([OH:36])=[O:35]>C(O)C>[N+:34]([O-:37])([OH:36])=[O:35].[CH2:1]([O:4][C:5](=[O:33])[NH:6][C@@H:7]([C:15]([N:17]1[CH2:21][CH2:20][CH2:19][C@H:18]1[C:22](=[O:32])[NH:23][CH2:24][C@H:25]1[CH2:26][CH2:27][C@H:28]([NH2:31])[CH2:29][CH2:30]1)=[O:16])[C:8]([S:11][CH:12]([CH3:13])[CH3:14])([CH3:9])[CH3:10])[CH2:2][CH3:3]参加物
4
実験手順
0.49 g of [(S)-1-[(S)-2-[(trans-4-aminocyclohexylmethyl)carbamoyl]pyrrolidine-1-carbonyl]-2-isopropylthio-2-methylpropyl]carbamic acid propyl ester obtained in Example 1 was dissolved in 5 ml of ethanol, and 1.0 ml of 1N nitric acid was added thereto, followed by stirring at room temperature for 30 minutes. The solvent was distilled off under reduced pressure, and then, 5 ml of toluene was added thereto and then distilled off under reduced pressure. The residue was dried under a reduced pressure of about 10 mmHg at room temperature to obtain 0.56 g of a white amorphous substance.