Pentadecanoic Acid → Pentadecanoyl chloride

HRID 1953925ノート

反応式

HRID 1953925 の反応式
S(Cl)([Cl:3])=O.[C:5]([OH:21])(=O)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]>C1(C)C=CC=CC=1>[C:5]([Cl:3])(=[O:21])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19]

参加物

4

反応物 2

HCID 13849Pentadecanoic AcidHCID 24386Thionyl Chloride

生成物 1

HCID 263097Pentadecanoyl chloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

C 18 resin: Pentadecanoyl chloride was synthesized by reacting 10 ml of 2 M thionyl chloride in 10 ml of toluene with 1.5 gm pentadecanoic acid. After 40 minutes of refluxing, the remaining thionyl chloride and toluene were removed by distillation. 4 gm of the 3-amino-propyl resin was then incubated overnight with the freshly prepared pentadecanoyl chloride in pyridine. The next day, the resin was twice washed with methylene chloride and then three times more with methanol and dried.

後処理

  1. temperatureAfter 40 minutes of refluxing
  2. customthe remaining thionyl chloride and toluene were removed by distillation
  3. washThe next day, the resin was twice washed with methylene chloride
  4. dry with materialthree times more with methanol and dried

出典と根拠

ORDレコード
ord-d0cfdd032eed4c3b97c2047641393aec
出典データセット
uspto-grants-2000_09
特許番号
US06119699

反応ノート

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