Imidazole → 5-Amino-4-fluoro-2-(1-imidazolyl)nitrobenzene
反応式
[NH2:1][C:2]1[C:3]([F:12])=[CH:4][C:5](F)=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.[NH:13]1[CH:17]=[CH:16][N:15]=[CH:14]1.[H-].[Na+]>O>[NH2:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([N:13]2[CH:17]=[CH:16][N:15]=[CH:14]2)=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1参加物
5
実験手順
12 g (0.068 mol) of 5-amino-2,4-difluoronitrobenzene were slowly added at 0° C. to a solution of 4.7 g of imidazole (0.069 mol) and 2.1 g of sodium hydride (80% in oil; 0.07 mol) and then stirred at this temperature for several hours. The mixture was then diluted with water and extracted several times with methylene chloride. The residue after drying and evaporation was recrystallized from isopropanol.
後処理
- extractionextracted several times with methylene chloride
- customThe residue after drying
- customevaporation
- customwas recrystallized from isopropanol
出典と根拠
- ORDレコード
- ord-ae16d0c9eb5d41978167ef239ba9d959
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06121265
反応ノート
読み込み中…