Oxalyl chloride → 1-Methylpiperidine-3-carbonyl chloride
反応式
[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5](O)=[O:6])[CH2:3]1.C(Cl)(=O)C([Cl:14])=O>ClCCl.CN(C=O)C>[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5]([Cl:14])=[O:6])[CH2:3]1参加物
5
実験手順
The hydrochloride salt of (±)-N-methylnipecotic acid (1.0 g) was suspended in dichloromethane (25 ml) and stirred at room temperature for 2 h with oxalyl chloride (0.58 ml) and DMF (1 drop). The solvent was then evaporated to yield the hydrochloride salt of N-methylnipecotyl chloride as a pale yellow solid.
後処理
- customThe solvent was then evaporated
出典と根拠
- ORDレコード
- ord-e2dfe99002a7405ab1ccb963ff74ebaf
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06121281
反応ノート
読み込み中…