Acetic Acid → N-(10-acetoxy-11-bromoundecyl)phthalimide

HRID 1954092

反応式

HRID 1954092 の反応式
[OH:1][CH:2]([CH2:23]O)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16](=[O:17])[C:15]2=[CH:18][CH:19]=[CH:20][CH:21]=[C:14]2[C:13]1=[O:22].[BrH:25].O.C([O-])(O)=O.[Na+].[C:32]([OH:35])(=O)[CH3:33]>>[C:32]([O:1][CH:2]([CH2:23][Br:25])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:13](=[O:22])[C:14]2=[CH:21][CH:20]=[CH:19][CH:18]=[C:15]2[C:16]1=[O:17])(=[O:35])[CH3:33]

参加物

6

反応物 5

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 962WaterHCID 516892Sodium BicarbonateHCID 12988906N-(10,11-Dihydroxyundecyl)phthalimide

生成物 1

HCID 23295904N-(10-acetoxy-11-bromoundecyl)phthalimide

実験手順

N-(10,11-Dihydroxyundecyl)phthalimide (2.35 g, 7.10 mmol) was stirred for 3 hours with HBr (6.90 mL of a 30% solution in acetic acid, 21.3 mmol). The mixture was then added over 10 minutes to a solution of water (50 mL), ice (25 g) and NaHCO3 (15 g) and stirred for an additional 30 min. The resulting reaction product was extracted with dichloromethane (3×70 mL) and the combined organic phase was dried using magnesium sulfate and evaporated, yielding a residue of N-(10-acetoxy-11-bromoundecyl)phthalimide.

後処理

  1. customThe resulting reaction product
  2. extractionwas extracted with dichloromethane (3×70 mL)
  3. customthe combined organic phase was dried
  4. customevaporated

出典と根拠

ORDレコード
ord-997b8166fa5a4c1a89097b5d30f1a2e1
出典データセット
uspto-grants-2000_09
特許番号
US06121270

関連ノート

読み込み中…