5-Fluoro-indolyl-3-propylazide → 5-Fluoro-indolyl-3-propylamine
反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](C(N=[N+]=[N-])CC)=[CH:5]2>[Pd].C(O)C>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([NH:7][CH2:6][CH2:5][CH3:4])=[CH:5]2参加物
4
実験手順
A solution of 5-fluoro-indolyl-3-propylazide (8 g, 0.037 mol) and 10% palladium on carbon in ethanol was hydrogenated at 50 psi for 16 hours. The catalyst was filtered and the solvent removed under vacuum. The celite was washed with methanol (300 ml) and the solvent was removed under vacuum. Chromatography (15% methanol-methylene chloride plus ammonium hydroxide) afforded 4.33 g (61%) of product as a yellow solid: mp 82-84.5° C.
後処理
- filtrationThe catalyst was filtered
- customthe solvent removed under vacuum
- washThe celite was washed with methanol (300 ml)
- customthe solvent was removed under vacuum
出典と根拠
- ORDレコード
- ord-81c9fd9dac2a4cb9b8e3e7d862316920
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06121307
反応ノート
読み込み中…