Potassium Hydroxide → HCID 18430706、化合物

HRID 1954263ノート

反応式

HRID 1954263 の反応式
[Br:1][C:2]1[C:11]2[S:12][C:13]([CH3:16])=[C:14]([CH3:15])[C:10]=2[C:9]([C:17]2[CH:22]=[C:21]([CH3:23])[C:20]([O:24]C(=O)C)=[C:19]([CH3:28])[CH:18]=2)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[CH:7]2.[OH-].[K+]>O1CCCC1.CO>[Br:1][C:2]1[C:11]2[S:12][C:13]([CH3:16])=[C:14]([CH3:15])[C:10]=2[C:9]([C:17]2[CH:22]=[C:21]([CH3:23])[C:20]([OH:24])=[C:19]([CH3:28])[CH:18]=2)=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[CH:7]2

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 10297816HCID 10297816、化合物

生成物 1

HCID 18430706HCID 18430706、化合物収率 93.5%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of acetic acid 4-(9-bromo-2,3-dimethyl-naphtho[2, 3-b]thiophen-4-yl)-2,6-dimethyl-phenyl ester (6.5 g, 14.3 mmol) in tetrahydrofuran (240 mL) and methanol (80 mL) at room temperature was added dropwise aqueous potassium hydroxide (17.2 mL of a 1N solution, 17.2 mmol). After 4 h at room temperature the reaction mixture was placed in the freezer for 18 h. The reaction was removed from the freezer and allowed to stir at room temperature. More aqueous potassium hydroxide (41.5 nL of a 1N solution, 41.5 mmol), tetrahydrofuran (50 mL), and methanol (10 mL) were added. The mixture was diluted with water (500 mL), acidified with 1N aqueous solution of hydrochloric acid, and extracted with diethyl ether. The diethyl ether layer was washed twice with water (500 mL), and dried (MgSO4). Concentration under reduced pressure gave a residue which was adsorbed onto silica gel. Chromatography with petroleum ether:ethyl acetate (97:3, then 95:5) gave the title compound as a white foamy solid (5.5 g, 93%): NMR (CDC13) δ 8.41 (s, 1 H), 8.16 (d, 1 H), 7.64-7.54 (m, 2 H), 7.46-7.40 (m, 1 H), 6.89 (s, 2 H), 2.41 (s, 3 H), 2.23 (s, 6 H), 1.60 (s, 3 H). MS(-ESI), [M-H], 1 bromine isotope pattern, 409/411.

後処理

  1. customThe reaction was removed from the freezer
  2. additionMore aqueous potassium hydroxide (41.5 nL of a 1N solution, 41.5 mmol), tetrahydrofuran (50 mL), and methanol (10 mL) were added
  3. additionThe mixture was diluted with water (500 mL)
  4. extractionextracted with diethyl ether
  5. washThe diethyl ether layer was washed twice with water (500 mL)
  6. dry with materialdried (MgSO4)
  7. concentrationConcentration under reduced pressure
  8. customgave a residue which

出典と根拠

ORDレコード
ord-175ca7ab47064f5e9f104a16027c4bc7
出典データセット
uspto-grants-2000_09
特許番号
US06121271

反応ノート

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