Ethanol → 1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

HRID 19548

反応式

HRID 19548 の反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:7](Br)[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])[CH3:2].[CH2:24]([OH:26])[CH3:25]>[N+]([O-])([O-])=O.[Ag+]>[CH2:1]([O:3][C:4]([C:6]1[CH:7]([O:26][CH2:24][CH3:25])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 702EthanolHCID 686984701-bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

生成物 1

HCID 116601011-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester収率 52%

試薬・触媒・溶媒 1

HCID 24470Silver Nitrate触媒

実験手順

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

後処理

  1. filtrationfiltered
  2. customThe organic layer was separated
  3. concentrationconcentrated under a reduced pressure
  4. customThe resulting residue was purified by flash chromatography

出典と根拠

ORDレコード
ord-87633b90324c42a59e3bb02d07e2d09b
出典データセット
uspto-grants-2010_06
特許番号
US07745439B2

関連ノート

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