Oxalyl chloride → (E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride

HRID 1954868ノート

反応式

HRID 1954868 の反応式
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([OH:15])=O.C(Cl)(=O)C([Cl:19])=O>ClCCl.CN(C)C=O>[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([Cl:19])=[O:15]

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 10976722(E)-2-(4,6-difluoro-1-indanylidene)acetic acid

生成物 1

HCID 10977254(E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

A suspension of (E)-2-(4,6-difluoro-1-indanylidene)acetic Acid (5.49 g, 0.026 mol) in a mixture of dichloromethane: dimethylformamide (50 mL: 5 drops) was treated with oxalyl chloride (6.6 g 0.052 mol, Aldrich) and allowed to stir at ambient temperature for 18 h. The resulting solution was concentrated in vacuo and the residue used without further purification.

後処理

  1. concentrationThe resulting solution was concentrated in vacuo
  2. customthe residue used without further purification

出典と根拠

ORDレコード
ord-e3fdb48fe6554226bde281be60a6501c
出典データセット
uspto-grants-2000_09
特許番号
US06124284

反応ノート

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