Sodium Hydroxide → 3-(2-Fluorophenyl)propanoic acid

HRID 1954874ノート

反応式

HRID 1954874 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([O:12]CC)=[O:11].[OH-].[Na+]>O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][C:10]([OH:12])=[O:11]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 14879014Ethyl 3-(2-fluorophenyl)propanoate

生成物 1

HCID 20638663-(2-Fluorophenyl)propanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of ethyl 3-(2-fluorophenyl)propionate (25.54 g, 0.130 mol) and a 50% aqueous solution of sodium hydroxide (30 mL) in water (130 mL) was refluxed for 2 h. After cooling the mixture was washed with diethyl ether (2×100 mL). The aqueous phase was chilled in an ice bath, and the pH was adjusted to 3 with hydrochloric acid. The white precipitate which formed was collected by filtration, washed repeatedly with water, and dried in a vacuum at 60° C. for 18 h to give 18.66 g (85%) of 3-(2-fluorophenyl)prionic acid as a white solid; m.p., 72-74° C. This material was used without further purification.

後処理

  1. temperatureAfter cooling the mixture
  2. washwas washed with diethyl ether (2×100 mL)
  3. temperatureThe aqueous phase was chilled in an ice bath
  4. customThe white precipitate which formed
  5. filtrationwas collected by filtration
  6. washwashed repeatedly with water
  7. customdried in a vacuum at 60° C. for 18 h
  8. customto give 18.66 g (85%) of 3-(2-fluorophenyl)prionic acid as a white solid
  9. customm.p., 72-74° C
  10. customThis material was used without further purification

出典と根拠

ORDレコード
ord-abd92a716aaf48e7b9cb24c54fe4866f
出典データセット
uspto-grants-2000_09
特許番号
US06124284

反応ノート

読み込み中…