Ethyl 3-hydroxyimino-5-methoxy-1-phenylindene-2-carboxylate → 1-amino-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[N:23]O)[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])[CH3:2]>CO.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[CH:7]([NH2:23])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([O:21][CH3:22])[CH:9]=2)=[O:5])[CH3:2]参加物
4
実験手順
1-Hydroxyimino-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (1.00 g, 3.09 mmol) obtained in Step 1 was dissolved in methanol (100 mL), and 10%-palladium (583 mg) was added thereto. The mixture was stirred for 15 hrs at RT while providing H2 gas thereto using a balloon, filtered through celite, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 786 mg of the titled compound (yield: 82%).