p-Toluenesulfonic acid → 6-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid methyl ester

HRID 19553

反応式

HRID 19553 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7](=[O:22])[C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][CH:11]=[C:10]([OH:21])[CH:9]=2)=[O:5])C.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH3:1][O:3][C:4]([C:6]1[C:7](=[O:22])[C:8]2[C:13]([C:14]=1[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[CH:12][CH:11]=[C:10]([OH:21])[CH:9]=2)=[O:5]

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 118452796-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

生成物 1

HCID 687002636-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid methyl ester収率 98.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

6-Hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (500 mg, 1.70 mmol) prepared in Preparation Example 2 was dissolved in methanol (30 mL), p-toluenesulfonic acid (65 mg, 0.34 mmol) was added thereto, refluxed for 24 hrs, and the solvent was removed therefrom by evaporation. The resulting residue was purified by flash chromatography to obtain 470 mg of the titled compound (yield: 98.6%) as a red solid.

後処理

  1. temperaturerefluxed for 24 hrs
  2. customthe solvent was removed
  3. customby evaporation
  4. customThe resulting residue was purified by flash chromatography

出典と根拠

ORDレコード
ord-c58bfd6276374db59e66f17c0eef611d
出典データセット
uspto-grants-2010_06
特許番号
US07745439B2

関連ノート

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