Hydrogen Bromide → 4'-Bromomethyl-4-decyloxybiphenyl

HRID 1955471

反応式

HRID 1955471 の反応式
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[BrH:26]>>[Br:26][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 190699634-Hydroxymethyl-4'-decyloxybiphenyl

生成物 1

HCID 190699574'-Bromomethyl-4-decyloxybiphenyl

反応条件

温度
115 °C

実験手順

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then heated at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

後処理

  1. customAfter completion of the reaction
  2. extractionthe resultant mixture was extracted with ether
  3. washwashed with water, which
  4. washwas further washed with an aqueous solution
  5. additioncontaining saturated NaHCO3
  6. washwashed again with water
  7. concentrationThe reaction product was concentrated
  8. customseparated by colomun chromatography

出典と根拠

ORDレコード
ord-004fe70502444dc09e8ead826065f7b8
出典データセット
uspto-grants-1998_07
特許番号
US05776365

関連ノート

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