Imidazo[2,1-b]thiazole-6-methanol, 2,3-dihydro-, 1,1-dioxide → HCID 18183096、化合物

HRID 1955480ノート

反応式

HRID 1955480 の反応式
[OH:1][CH2:2][C:3]1[N:4]=[C:5]2[N:9]([CH:10]=1)[CH2:8][CH2:7][S:6]2(=[O:12])=[O:11]>C(#N)C.[O-2].[O-2].[Mn+4]>[S:6]1(=[O:12])(=[O:11])[CH2:7][CH2:8][N:9]2[CH:10]=[C:3]([CH:2]=[O:1])[N:4]=[C:5]12

参加物

4

反応物 1

HCID 18183097Imidazo[2,1-b]thiazole-6-methanol, 2,3-dihydro-, 1,1-dioxide

生成物 1

HCID 18183096HCID 18183096、化合物

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒2 回HCID 6342Acetonitrile溶媒

実験手順

2,3-Dihydro-6-hydroxymethylimidazo[2,1-b]thiazole-1,1-dioxide (207 mg, 1.1 mmol) was dissolved in acetonitrile (minimum volume) and treated with manganese dioxide (621 mg, 3 wt. equivalents) and the mixture stirred vigorously at ambient temperature. After 1 h, more manganese dioxide (621 mg) was added and the mixture sitrred for a further 18 h. The mixture was filtered through Celite, the filter bed washed with acetonitrile, the filtrate and washings combined and evaporated to dryness under reduced pressure. The residue was triturated under dichloromethane and the resulting solid collected by filtration, washed with dichloromethane and dried in air (108 mg, 53%) (Found: M+ 186.0103. C6H6 N2O3S requires M 186.0099); nmax (Nujol) 1691, 1320 and 1132 cm-1 ; dH [250MHz; (CD3)2SO] 4.25 (2H, t, J 7Hz), 4.68 (2H, t, J 7Hz), 8.32 (1H, s), 9.81 (1H, s).

後処理

  1. waitthe mixture sitrred for a further 18 h
  2. filtrationThe mixture was filtered through Celite
  3. washthe filter bed washed with acetonitrile
  4. customevaporated to dryness under reduced pressure
  5. customThe residue was triturated under dichloromethane
  6. filtrationthe resulting solid collected by filtration
  7. washwashed with dichloromethane
  8. customdried in air (108 mg, 53%) (Found: M+ 186.0103. C6H6 N2O3S requires M 186.0099)

出典と根拠

ORDレコード
ord-7a9c097a7691410cab229dc5f030de04
出典データセット
uspto-grants-1998_07
特許番号
US05776455

反応ノート

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