Hydrochloric Acid → 3-Methoxyimino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

HRID 1955590

反応式

HRID 1955590 の反応式
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].[CH3:9][O:10][N:11]=[C:12]([C:18](OCC)=[O:19])[C:13](OCC)=[O:14].Cl>C[O-].[Na+]>[CH3:9][O:10][N:11]=[C:12]1[C:18](=[O:19])[NH:8][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=2[NH:7][C:13]1=[O:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 7243O-PhenylenediamineHCID 533643Diethyl 2-(methoxyimino)malonate

生成物 1

HCID 190708143-Methoxyimino-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

試薬・触媒・溶媒 1

HCID 10942334Sodium Methoxide溶媒

実験手順

A mixture of iN sodium methylate (162 ml), o-phenylenediamine (17.5 g, 162 mmol) and diethyl 2-(methoxyimino)malonate (32.91 g, 162 mmol) is heated to reflux for 5 hr. After cooling, the mixture is acidified with 2N HCl (162 ml) and pale yellowish crystals (14.3 g, 41%) are filtered off.

後処理

  1. temperatureis heated
  2. temperatureto reflux for 5 hr
  3. temperatureAfter cooling
  4. filtrationare filtered off

出典と根拠

ORDレコード
ord-1fc1aabf11b34aa49ae3405463bbb15f
出典データセット
uspto-grants-1998_07
特許番号
US05776929

関連ノート

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