Phosphorus trichloride → Dimethyl Quinoline-2,3-dicarboxylate

HRID 1955604ノート

反応式

HRID 1955604 の反応式
[N+:1]1([O-])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13][CH3:14])=[O:12])[C:2]=1[C:15]([O:17][CH3:18])=[O:16].P(Cl)(Cl)Cl>C(Cl)(Cl)Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13][CH3:14])=[O:12])[C:2]=1[C:15]([O:17][CH3:18])=[O:16]

参加物

4

反応物 2

HCID 24387Phosphorus trichlorideHCID 15366557HCID 15366557、化合物

生成物 1

HCID 11010215Dimethyl Quinoline-2,3-dicarboxylate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of N-oxide 3 (10 mM) and phosphorus trichloride (30 mM) in anhydrous chloroform (100 ml) was refluxed for 7 h. Solvent was removed under reduced pressure and the residue was partitioned between ethyl acetate and water. The organic layer was dried over sodium sulphate and then evaporated under reduced pressure. The residue was recrystallized from isopropanol to provide the title dimethyl quinoline-2,3-dicarboxylate 7 as an off white (or light yellow) powder.

後処理

  1. customSolvent was removed under reduced pressure
  2. customthe residue was partitioned between ethyl acetate and water
  3. dry with materialThe organic layer was dried over sodium sulphate
  4. customevaporated under reduced pressure
  5. customThe residue was recrystallized from isopropanol

出典と根拠

ORDレコード
ord-4ee3d8d301824f80b57afcbb6894ed3d
出典データセット
uspto-grants-1998_07
特許番号
US05776935

反応ノート

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