3-Methyl-5-phenylmethoxy-1-(4-pyridinylamino)-1H-indole → 3-Methyl-1-(4-pyridinylamino)-1H-indol-5-ol

HRID 1955675ノート

反応式

HRID 1955675 の反応式
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11]CC3C=CC=CC=3)[CH:9]=2)[N:4]([NH:19][C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[CH:3]=1>C(O)C.[Pd]>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([OH:11])[CH:9]=2)[N:4]([NH:19][C:20]2[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=2)[CH:3]=1

参加物

4

反応物 1

HCID 190724043-Methyl-5-phenylmethoxy-1-(4-pyridinylamino)-1H-indole

生成物 1

HCID 190723853-Methyl-1-(4-pyridinylamino)-1H-indol-5-ol収率 31.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

3-Methyl-5-phenylmethoxy-1-(4-pyridinylamino)-1H-indole (2.2 g) dissolved in absolute ethanol (80 ml) was hydrogenated at 344.74 Kpa (Parr shaker, 50 psi) over ten percent palladium on carbon (0.26 g) at 50° C. for two hours. The catalyst was removed by filtration and the solids were washed with methanol. Concentration and recrystallization from methanol afforded the title compound as a solid (0.5 g), m.p. 239°-241° C. (dec.).

後処理

  1. customThe catalyst was removed by filtration
  2. washthe solids were washed with methanol
  3. concentrationConcentration and recrystallization from methanol

出典と根拠

ORDレコード
ord-3352568aabc24b76a36bc2ade598f1e3
出典データセット
uspto-grants-1998_07
特許番号
US05776955

反応ノート

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