Methyl 6-thien-2-ylnicotinate → 6-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid

HRID 1956335

反応式

HRID 1956335 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]([O:14]C)=[O:13])=[CH:8][CH:7]=1>CO.[OH-].[Na+]>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[CH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][CH:7]=1

参加物

4

反応物 1

HCID 17879034Methyl 6-thien-2-ylnicotinate

生成物 1

HCID 154111446-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of 2.0 g of methyl 6-(2-thienyl)pyridine-3-carboxylate in 100 ml of methyl alcohol and 50 ml of 5N sodium hydroxide is stirred at room temperature for 16 hours under nitrogen. The reaction mixture is evaporated in vacuo to about one quarter of the volume and then diluted with 150 ml of cold water. The pH is adjusted to 4 with acetic acid and the desired white product collected, washed with 400 ml of cold water until neutral. The solid is washed with 50 ml of petroleum ether and dried under vacuum to 40° C. to give the desired product.

後処理

  1. customThe reaction mixture is evaporated in vacuo to about one quarter of the volume
  2. additiondiluted with 150 ml of cold water
  3. customthe desired white product collected
  4. washwashed with 400 ml of cold water until neutral
  5. washThe solid is washed with 50 ml of petroleum ether
  6. customdried under vacuum to 40° C.

出典と根拠

ORDレコード
ord-7b94a8b3de82497ca819bb6c4269651c
出典データセット
uspto-grants-1998_07
特許番号
US05780471

関連ノート

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