2,4-Difluorobenzylamine → 3-(2,4-Difluoro-benzylamino)-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione

HRID 1956715

反応式

HRID 1956715 の反応式
C(O[C:4]1[C:5](=[O:15])[C:6](=[O:14])[C:7]=1[NH:8][C:9]([CH3:13])([CH3:12])[CH2:10][CH3:11])C.[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1[CH2:19][NH2:20]>C(#N)C>[F:16][C:17]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:18]=1[CH2:19][NH:20][C:4]1[C:5](=[O:15])[C:6](=[O:14])[C:7]=1[NH:8][C:9]([CH3:12])([CH3:13])[CH2:10][CH3:11]

参加物

4

反応物 2

HCID 27332442,4-DifluorobenzylamineHCID 178194033-Ethoxy-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione

生成物 1

HCID 106625733-(2,4-Difluoro-benzylamino)-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

This compound was prepared according to the procedure for Example 59. From 3-ethoxy-4-(1,1 -dimethyl-propylamino)-cyclobut-3-ene- 1,2-dione and 2,4-difluorobenzylamine in acetonitrile. The title compound was obtained, after recrystallization from diethyl ether, as a white solid (80%): mp 242°-244° C.; 1H NMR (DMSO-d6) δ0.82 (t, 3H), 1.30 (s, 6H), 1.68 (q, 2H), 4.76 (d, 2H), 7.09 (m, 1H), 7.27 (m, 1H), 7.50 (m, 2H), 7.80 (m, 1H) ppm; IR (KBr) 3250, 3150, 2970, 1790, 1652, 1580, 1538, 1510 cm-1 ; MS (m/z) 309 ([M+H]+).

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-b753f3c2598f46c98cd0e6750741f097
出典データセット
uspto-grants-1998_07
特許番号
US05780505

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