2-Chloro-4-fluorobenzylamine → 3-(2-Chloro-4-fluoro-benzylamino)-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione

HRID 1956716

反応式

HRID 1956716 の反応式
[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].C([O:13][C:14]1[C:15](=[O:25])[C:16](=O)[C:17]=1[NH:18][C:19]([CH3:23])([CH3:22])[CH2:20][CH3:21])C>C(#N)C>[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:16]1[C:15](=[O:25])[C:14](=[O:13])[C:17]=1[NH:18][C:19]([CH3:22])([CH3:23])[CH2:20][CH3:21]

参加物

4

反応物 2

HCID 1399092-Chloro-4-fluorobenzylamineHCID 178194033-Ethoxy-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione

生成物 1

HCID 108059433-(2-Chloro-4-fluoro-benzylamino)-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

This compound was prepared according to the procedure for Example 59. From 2-chloro-4-fluorobenzylamine and 3-ethoxy-4-(1,1-dimethyl-propylamino)-cyclobut-3-ene-1,2-dione in acetonitrile. The title compound was obtained, after recrystallization from petroleum ether, as a white solid (60%); mp 201°-203° C.; 1H NMR (DMSO-d6) δ0.81 (t, 3H), 1.30 (s, 6H), 1.68 (q, 2H), 4.76 (d, 2H), 7.25 (m, 1H), 7.50 (m, 3H), 7.78 (m, 1H) ppm; IR (KBr) 3250, 3040, 1790, 1660, 1580, 1530, 1490 cm-1 ; MS (m/z) 325 ([M+H]+).

後処理

  1. customThis compound was prepared

出典と根拠

ORDレコード
ord-c04173aff885422cbedb73b732e95d10
出典データセット
uspto-grants-1998_07
特許番号
US05780505

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