Acetonitrile → benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate

HRID 1956789

反応式

HRID 1956789 の反応式
[CH2:1]([O:8][C:9]([NH:11][C:12](=[NH:15])SC)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:16](#[N:18])[CH3:17]>>[CH2:1]([O:8][C:9]([NH:11][C:12]([N:18]1[CH2:5][CH2:4][CH:3]([CH2:2][CH2:1][OH:8])[CH2:17][CH2:16]1)=[NH:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 6342AcetonitrileHCID 140362141Benzyl [amino(methylsulfanyl)methylene]carbamate

生成物 1

HCID 140379078benzyl N-[4-(2-hydroxyethyl)piperidine-1-carboximidoyl]carbamate収率 41%

実験手順

(0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.

後処理

  1. customEvaporation and flash chromatography on silica gel with ethyl acetate

出典と根拠

ORDレコード
ord-5b328a7e8eca4f1a8f53da167f22f591
出典データセット
uspto-grants-1998_07
特許番号
US05780631

関連ノート

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