Benzoyl Peroxide → 3-(4-(Bromomethyl)phenyl)thiophene

HRID 1957019ノート

反応式

HRID 1957019 の反応式
[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=2)=[CH:2]1.[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[S:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][Br:13])=[CH:8][CH:7]=2)=[CH:2]1

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 41303473-(4-Methylphenyl)thiophene

生成物 1

HCID 137735383-(4-(Bromomethyl)phenyl)thiophene

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 4-(3-thienyl)toluene (3.56 g, 20.5 mmol) in carbon tetrachloride (100 ml) is added N-bromosuccinimide (3.64 g, 20.5 mol) and benzoyl peroxide (80 mg, 3.3 mmol). The reaction mixture is heated at reflux for 24 hrs. and concentrated in vacuo. The reaction mixture is recrystallized from ethanol to afford 4-(3-thienyl)benzyl bromide.

後処理

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 24 hrs
  3. concentrationand concentrated in vacuo
  4. customThe reaction mixture is recrystallized from ethanol

出典と根拠

ORDレコード
ord-ef8bed6f4a65437fb5f42700a13c9323
出典データセット
uspto-grants-1998_07
特許番号
US05780498

反応ノート

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