Potassium Cyanide → 2-(3,4-Dichlorophenyl)-2-hydroxyacetonitrile

HRID 1957041ノート

反応式

HRID 1957041 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH:5]=[O:6].[C-:11]#[N:12].[K+]>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]([OH:6])[C:11]#[N:12])[CH:7]=[CH:8][C:9]=1[Cl:10]

参加物

4

反応物 2

HCID 9032Potassium CyanideHCID 227103,4-Dichlorobenzaldehyde

生成物 1

HCID 136165902-(3,4-Dichlorophenyl)-2-hydroxyacetonitrile収率 94%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 70 g of 3,4-dichlorobenzaldehyde and 90 g of Na2S2 O5 in 300 ml of water is stirred overnight at RT. The reaction mixture is cooled to 0° C., a solution of 52 g of KCN in 100 ml of water is added dropwise and the reaction mixture is stirred while the temperature is allowed to rise to RT. It is extracted with ether, the organic phase is washed with water and dried over Na2SO4 and the solvent is evaporated off under vacuum to give 76 g of the expected product, which is used as such.

後処理

  1. temperatureThe reaction mixture is cooled to 0° C.
  2. stirringthe reaction mixture is stirred while the temperature
  3. customto rise to RT
  4. extractionIt is extracted with ether
  5. washthe organic phase is washed with water
  6. dry with materialdried over Na2SO4
  7. customthe solvent is evaporated off under vacuum

出典と根拠

ORDレコード
ord-c8d6e0c87ab94a3989fb38353a2af180
出典データセット
uspto-grants-1998_07
特許番号
US05780466

反応ノート

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