2,5-Dichlorophenol → 2,5-Dichloro-4-nitrophenol
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[OH:9].[N+:10]([O-])([OH:12])=[O:11]>ClCCl>[Cl:1][C:2]1[CH:7]=[C:6]([N+:10]([O-:12])=[O:11])[C:5]([Cl:8])=[CH:4][C:3]=1[OH:9]参加物
4
実験手順
2,5-dichlorophenol (72 g, 440 mmol) were slurried in 100 ml dichloromethane which resulted in an endothermic reaction. To this mixture were slowly added 30 ml (480 mmol) concentrated nitric acid. The reaction was allowed to reach and maintain reflux. The mixture was stirred until it reached ambient temperature and all materials remained in solution. 50 g of ice were added and solids precipitated. The mixture was filtered cold and washed with 25 ml dichloromethane, 50 ml dichloromethane, then twice with 25 ml dichloromethane to yield 28.4 g of 2,5-dichloro-4-nitrophenol.
後処理
- customresulted in an endothermic reaction
- temperaturemaintain
- temperaturereflux
- customreached ambient temperature
- customsolids precipitated
- filtrationThe mixture was filtered cold
- washwashed with 25 ml dichloromethane, 50 ml dichloromethane
出典と根拠
- ORDレコード
- ord-dac27d0877c748b2bf7ed384d762bcf7
- 出典データセット
- uspto-grants-1998_07
- 特許番号
- US05786301
反応ノート
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