Acetonitrile → HCID 178507819、化合物

HRID 1957518ノート

反応式

HRID 1957518 の反応式
[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[C:5](C(O)=O)=[CH:4][C:3]=1[Cl:15].[C:16](#[N:18])[CH3:17]>>[NH2:1][C:2]1[C:7]2[O:8][CH2:9][CH2:10][O:11][C:6]=2[CH:5]=[CH:4][C:3]=1[Cl:15].[NH:18]1[C-:16]=[CH:17][N:1]=[CH:2]1

参加物

3

反応物 2

HCID 6342AcetonitrileHCID 117759978-Amino-7-chloro-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid

生成物 1

HCID 178507819HCID 178507819、化合物

実験手順

To a stirred solution of 8-amino-7-chloro-1,4-benzodioxan-5-carboxylic acid (prepared from the corresponding 7-H acid (prepared as in GB 1571278) by chlorination of the protected form) (1.10 g) in acetonitrile was added biscarbonyldiimidazole (0.77 g). The reaction mixture was stirred at room temperature for 1.5 hours. The solvent was removed under reduced pressure to afford crude 8-amino-7-chloro-1,4-benzodioxan-5-imidazolide.

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-41361a8672a44e33b8496e820a715ce8
出典データセット
uspto-grants-1998_07
特許番号
US05786372

反応ノート

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