Tetrahydrofuran → Allyl 4-[3-(1-adamantyl)-4-methoxyethoxymethoxybenzamido]benzoate

HRID 1957695ノート

反応式

HRID 1957695 の反応式
[NH2:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([O:8][CH2:9][CH:10]=[CH2:11])=[O:7])=[CH:4][CH:3]=1.C(N(CC)CC)C.C1COCC1.[C:26]12([C:36]3[CH:37]=[C:38]([CH:42]=[CH:43][C:44]=3[O:45][CH2:46][O:47][CH2:48][CH2:49][O:50][CH3:51])[C:39](Cl)=[O:40])[CH2:35][CH:30]3[CH2:31][CH:32]([CH2:34][CH:28]([CH2:29]3)[CH2:27]1)[CH2:33]2>O>[C:26]12([C:36]3[CH:37]=[C:38]([CH:42]=[CH:43][C:44]=3[O:45][CH2:46][O:47][CH2:48][CH2:49][O:50][CH3:51])[C:39]([NH:1][C:2]3[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][CH:10]=[CH2:11])=[O:7])=[CH:12][CH:13]=3)=[O:40])[CH2:27][CH:28]3[CH2:29][CH:30]([CH2:31][CH:32]([CH2:34]3)[CH2:33]1)[CH2:35]2

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 13075143Prop-2-en-1-yl 4-aminobenzoateHCID 572331023-(1-Adamantyl)-4-methoxyethoxymethoxybenzoyl chloride

生成物 1

HCID 67663874Allyl 4-[3-(1-adamantyl)-4-methoxyethoxymethoxybenzamido]benzoate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

700 mg (3.95 mmol) of allyl 4-aminobenzoate, 1 ml (4.3 mmol) of triethylamine and 50 ml of THF were introduced into a round-bottomed flask. A solution of 1.5 g (3.96 mmol) of 3-(1-adamantyl)-4-methoxyethoxymethoxybenzoyl chloride was added dropwise and the mixture was stirred at room temperature for 4 hours. The reaction medium was poured into water and extracted with ethyl ether. The organic phase was separated out after settling had taken place, dried over magnesium sulfate and evaporated. The residue obtained was purified by chromatography on a column of silica, eluted with dichloromethane. 1.7 g (83%) of the expected allylic ester was recovered in the form of an oil.

後処理

  1. extractionextracted with ethyl ether
  2. customThe organic phase was separated out
  3. dry with materialdried over magnesium sulfate
  4. customevaporated
  5. customThe residue obtained
  6. customwas purified by chromatography on a column of silica
  7. washeluted with dichloromethane
  8. custom1.7 g (83%) of the expected allylic ester was recovered in the form of an oil

出典と根拠

ORDレコード
ord-b46855fa87a44f10b58563b1917e71b5
出典データセット
uspto-grants-1998_07
特許番号
US05786379

反応ノート

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