Water → 2-Hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene

HRID 1957801ノート

反応式

HRID 1957801 の反応式
[C:1]1([NH:7][C:8]([C:10]2[C:11](C([O-])=O)=[CH:12][C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([C:20]([O:22]C)=[O:21])=[CH:15][CH:14]=3)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[OH2:28].[OH-].[Na+]>CO>[OH:28][C:11]1[C:10]([C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])=[CH:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:20]([OH:22])=[O:21])[CH:17]=2)[CH:12]=1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 23666583HCID 23666583、化合物

生成物 1

HCID 109797242-Hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene収率 85%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium 3-phenylaminocarbonyl-6-methoxycarbonyl-2-naphthoate (0.081 g) obtained in Example 29 was suspended in methanol (8.10 g) and deionized water (8.13 g) and 1N-sodium hydroxide (4.0 g) was added dropwise under ice-cooling, followed by stirring overnight. The reaction solution was freeze-dried and the resultant solid was dissolved in water. The solution was acidified with diluted hydrochloric acid and the deposited crystal was filtered. The crystal was dried under reduced pressure to obtain 0.057 g of 2-hydroxy-3-phenylaminocarbonyl-6-hydroxycarbonylnaphthalene.

後処理

  1. temperaturecooling
  2. customThe reaction solution was freeze-dried
  3. dissolutionthe resultant solid was dissolved in water
  4. filtrationthe deposited crystal was filtered
  5. customThe crystal was dried under reduced pressure

出典と根拠

ORDレコード
ord-1ef0e0c263484903ba5c6f3d479e3ffb
出典データセット
uspto-grants-1998_07
特許番号
US05786523

反応ノート

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