1-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene → 3-(Methylsulfonyl)methyl-5-trifluoromethyl-aniline

HRID 1957957ノート

反応式

HRID 1957957 の反応式
[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([N+:16]([O-])=O)[CH:7]=1)(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([CH2:5][C:6]1[CH:7]=[C:8]([CH:9]=[C:10]([C:12]([F:13])([F:14])[F:15])[CH:11]=1)[NH2:16])(=[O:4])=[O:3]

参加物

4

反応物 1

HCID 684233041-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene

生成物 1

HCID 592861493-(Methylsulfonyl)methyl-5-trifluoromethyl-aniline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A suspension of 1-methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene (520 mg; 2.170 mmol) and 50 mg of Pd/C 10% in methanol (50 ml) was hydrogenated (1 bar) overnight. The reaction mixture was filtered on a celite pad and the obtained solution concentrated in vacuo. The crude was washed with dichloromethane in order to filter salts, coming from the previous reaction. 100 mg (0.395 mmol; 18% yield) were obtained.

後処理

  1. custom(1 bar) overnight
  2. filtrationThe reaction mixture was filtered on a celite pad
  3. concentrationthe obtained solution concentrated in vacuo
  4. washThe crude was washed with dichloromethane in order
  5. filtrationto filter salts
  6. customcoming from the previous reaction
  7. custom100 mg (0.395 mmol; 18% yield) were obtained

出典と根拠

ORDレコード
ord-6caa83cd7b8c43509d4ada3f7ce8c58b
出典データセット
uspto-grants-2013_04
特許番号
US08410100B2

反応ノート

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