Sodium Carbonate → Methyl N-cyano-2-methylmorpholine-4-carbimidothioate
反応式
Cl.[CH3:2][CH:3]1[O:8][CH2:7][CH2:6][NH:5][CH2:4]1.[C:9]([N:11]=[C:12](SC)[S:13][CH3:14])#[N:10].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:9]([N:11]=[C:12]([N:5]1[CH2:6][CH2:7][O:8][CH:3]([CH3:2])[CH2:4]1)[S:13][CH3:14])#[N:10]参加物
5
実験手順
A mixture of 2-methylmorpholine hydrochloride (1.0 g, 9.9 mmol), dimethyl cyanocarbonimidodithioate (1.45 g, 9.9 mmol) and sodium carbonate (0.2 g, 1.9 mmol) in ethanol (50 mL) was stirred at ambient temperature overnight. The reaction mixture was concentrated and purified through silica gel chromatography to give the desired product (1.25 g, 63%). LC-MS: 200 (MH+).
後処理
- concentrationThe reaction mixture was concentrated
- custompurified through silica gel chromatography
出典と根拠
- ORDレコード
- ord-59e310a4c4df43d89511b21394ac8827
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08410095B2
反応ノート
読み込み中…