(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate → (+/-)-1-(Cyclohexylmethyl)-4-(oxiran-2-ylmethyl)piperazine

HRID 1958277

反応式

HRID 1958277 の反応式
[CH:1]1([CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[O:14]1[CH2:16][CH:15]1[CH2:17]OS(C1C=CC=C([N+]([O-])=O)C=1)(=O)=O>>[CH:1]1([CH2:7][N:8]2[CH2:9][CH2:10][N:11]([CH2:17][CH:15]3[CH2:16][O:14]3)[CH2:12][CH2:13]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

3

反応物 2

HCID 286836(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonateHCID 27358851-(Cyclohexylmethyl)piperazine

生成物 1

HCID 86661984(+/-)-1-(Cyclohexylmethyl)-4-(oxiran-2-ylmethyl)piperazine収率 92%

実験手順

The same method as employed in the preparation of Intermediate 1 but starting from 1-cyclohexylmethyl piperazine and (±)-3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after flash chromatography the title compound as a yellow oil in a 92% yield.

出典と根拠

ORDレコード
ord-2536eeedebbf49a0b6412589d7783b57
出典データセット
uspto-grants-2013_04
特許番号
US08410110B2

関連ノート

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