HCID 86619885、化合物 → 1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

HRID 1959025ノート

反応式

HRID 1959025 の反応式
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][N:15](C(=O)C(F)(F)F)[CH2:16]2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[CH2:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:18]=2)[CH2:13][CH2:14][NH:15]1

参加物

3

反応物 1

HCID 86619885HCID 86619885、化合物2 回

生成物 1

HCID 52261,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

N-(tert-Butyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (the product from step i), 1.78 g) was dissolved in TFA and stirred at room temperature for 96 h. The reaction was reduced in vacuo and the residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane to give the subtitle compound as a white solid. Yield: 0.65 g

後処理

  1. customthe residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane

出典と根拠

ORDレコード
ord-f6ae1292f80f47468c03cc8cd7891b81
出典データセット
uspto-grants-2013_04
特許番号
US08410123B2

反応ノート

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