Bromine → 2-Amino-1,3-benzothiazole-7-carboxylic acid

HRID 1959792ノート

反応式

HRID 1959792 の反応式
[NH:1]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])[C:2]([NH2:4])=[S:3].BrBr>C(Cl)(Cl)Cl>[NH2:4][C:2]1[S:3][C:6]2[C:7]([C:8]([OH:10])=[O:9])=[CH:11][CH:12]=[CH:13][C:5]=2[N:1]=1

参加物

4

反応物 2

HCID 24408BromineHCID 8205751-(3-Carboxyphenyl)-2-thiourea

生成物 1

HCID 202855902-Amino-1,3-benzothiazole-7-carboxylic acid収率 98%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a suspension of 3-thioureidobenzoic acid (1.06 g, 5.41 mmol) in chloroform (25 mL) was added a solution of bromine (0.4 mL, 8.0 mmol) dropwise at room temperature. The resulting mixture was heated under reflux for 3 hrs and allowed to stir at room temperature for 60 hrs. The solvent was evaporated, water was added and the resulting solids were isolated by filtration. The crude product was washed with water and dried to yield 1.03 g (98%) of the title compound as a gray solid.

後処理

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for 3 hrs
  3. customThe solvent was evaporated
  4. additionwater was added
  5. customthe resulting solids were isolated by filtration
  6. washThe crude product was washed with water
  7. customdried

出典と根拠

ORDレコード
ord-d3edf496817045ab9b044d97f53fa9e3
出典データセット
uspto-grants-2013_04
特許番号
US08410272B2

反応ノート

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