Water → Benzenesulfonamide, 4-chloro-N-methyl-3-nitro-

HRID 1959799

反応式

HRID 1959799 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH3:15][NH2:16].O>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:16][CH3:15])(=[O:10])=[O:9])=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13]

参加物

5

反応物 3

HCID 962WaterHCID 6329MethylamineHCID 7323Benzenesulfonyl chloride, 4-chloro-3-nitro-

生成物 1

HCID 67301Benzenesulfonamide, 4-chloro-N-methyl-3-nitro-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-chloro-3-nitrobenzenesulfonyl chloride (2.0 g, 7.8 mmol) in THF (10 mL) was added excess methylamine (2M solution in THF). The reaction solution was stirred at room temperature for 1 hr. Water was then added and the product was extracted into chloroform. The combined extracts were washed, dried over sodium sulfate, filtered and evaporation to yield 2.3 g of the crude 4-chloro-N-methyl-3-nitrobenzenesulfonamide as an oil. The crude material was used in the subsequent step without further purification.

後処理

  1. extractionthe product was extracted into chloroform
  2. washThe combined extracts were washed
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. customevaporation

出典と根拠

ORDレコード
ord-9dc742665884452eb55fdb09ff333aa8
出典データセット
uspto-grants-2013_04
特許番号
US08410272B2

関連ノート

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