Hydrazine hydrate (1:1) → HCID 178434665、化合物
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([C:10](=[C:13](OC)[CH3:14])[C:11]#[N:12])=[N:7][C:6]=2[CH:17]=1.O.[NH2:19][NH2:20]>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([C:10]3[C:13]([CH3:14])=[N:20][NH:19][C:11]=3[NH2:12])=[N:7][C:6]=2[CH:17]=1参加物
4
実験手順
A suspension of 2-(5-fluorobenzothiazol-2-yl)-3-methoxybut-2-enenitrile (330 mg, 1.3 mmol) and hydrazine hydrate (70 μL) in methanol (40 mL) was heated to reflux overnight. The solution was then cooled to room temperature and the resulting solid was isolated by filtration. The crude material was recrystallized from ethanol to yield 260 mg (78%, 10% for five steps) of the title compound. MS (m/z, ES+): 249.0 (M+1, 100%).
後処理
- temperaturewas heated
- temperatureto reflux overnight
- customthe resulting solid was isolated by filtration
- customThe crude material was recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-9bcb0126ed544573bfe0abcb8290cff6
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08410272B2
反応ノート
読み込み中…