Methylamine → HCID 178483385、化合物

HRID 1959842ノート

反応式

HRID 1959842 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17]Br)=[N:13][NH:12][C:11]=1[NH2:19].[CH3:20][NH2:21]>C1COCC1>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[C:10]1[C:14]([CH2:15][CH2:16][CH2:17][NH:21][CH3:20])=[N:13][NH:12][C:11]=1[NH2:19]

参加物

4

反応物 2

HCID 6329MethylamineHCID 178509116HCID 178509116、化合物

生成物 1

HCID 178483385HCID 178483385、化合物収率 32%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 4-benzothiazol-2-yl-5-(3-bromopropyl)-2H-pyrazol-3-ylamine (130 mg, 0.39 mmol) and methylamine (5 mL of a 2 M solution in THF, 10 mmol) was stirred at room temperature for 60 hrs. The resulting solid was isolated by filtration, washed with THF, and then with water. The product was air dried to yield 38 mg (32%) of the title compound as an off white solid. MS (m/z, ES+): 288.2 (M+1, 100%).

後処理

  1. customThe resulting solid was isolated by filtration
  2. washwashed with THF
  3. customdried

出典と根拠

ORDレコード
ord-ba9730bcfda44e219843ae63e21a3455
出典データセット
uspto-grants-2013_04
特許番号
US08410272B2

反応ノート

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