Potassium Carbonate → {5-[1-Biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzoimidazol-2-yloxy]-2-methyl-phenyl}-phosphonic acid diethyl ester

HRID 1960152ノート

反応式

HRID 1960152 の反応式
[CH2:1]([O:3][P:4]([C:9]1[CH:14]=[C:13]([O:15][C:16]2[N:20]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[CH:24][CH:23]=3)[C:19]3[CH:34]=[C:35]([Cl:39])[C:36](I)=[CH:37][C:18]=3[N:17]=2)[CH:12]=[CH:11][C:10]=1[CH3:40])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].[CH3:41][N:42]1[C:50]2[C:45](=[CH:46][C:47](B(O)O)=[CH:48][CH:49]=2)[CH:44]=[CH:43]1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O.[Pd].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>[CH2:1]([O:3][P:4]([C:9]1[CH:14]=[C:13]([O:15][C:16]2[N:20]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[CH:24][CH:23]=3)[C:19]3[CH:34]=[C:35]([Cl:39])[C:36]([C:47]4[CH:46]=[C:45]5[C:50](=[CH:49][CH:48]=4)[N:42]([CH3:41])[CH:43]=[CH:44]5)=[CH:37][C:18]=3[N:17]=2)[CH:12]=[CH:11][C:10]=1[CH3:40])(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]

参加物

7

反応物 3

HCID 11430Potassium CarbonateHCID 27598671-Methyl-1H-indole-5-boronic acidHCID 86761791[5-(1-Biphenyl-4-ylmethyl-6-chloro-5-iodo-1H-benzoimidazol-2-yloxy)-2-methyl-phenyl]-phosphonic acid diethyl ester

生成物 1

HCID 86761792{5-[1-Biphenyl-4-ylmethyl-6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzoimidazol-2-yloxy]-2-methyl-phenyl}-phosphonic acid diethyl ester

試薬・触媒・溶媒 3

HCID 11979704Tetrakis(triphenylphosphine)palladium触媒HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
130 °C

実験手順

To a solution of {5-[1-biphenyl-4-ylmethyl-6-chloro-5-Iodo-1H-benzoimidazol-2-yloxy]-2-methyl-phenyl}-phosphonic acid diethyl ester (900 mg, 1.3 mmol) in DMF (6 ml) was added 1-methyl-1H-indole-5-boronic acid (460 mg, 2.6 mmol), tetrakis(triphenylphosphine)-palladium(0) (155 mg, 0.13 mmol), and lastly a solution of potassium carbonate (718 mg, 5.2 mmol) in 3 ml of H2O. The mixture was heated in a microwave oven at 130° C. for 15 min. The reaction was partitioned between EtOAc and half-saturated NH4Cl. The EtOAc layer was washed with H2O and then brine. The organic layer was dried with MgSO4, evaporated to an oil, and then purified by flash chromatography. The flash column was eluted with a solvent gradient up to 65% EtOAc in Hexane to isolate the title compound as a mixture of the two protected regioisomers.

後処理

  1. customThe reaction was partitioned between EtOAc and half-saturated NH4Cl
  2. washThe EtOAc layer was washed with H2O
  3. dry with materialThe organic layer was dried with MgSO4
  4. customevaporated to an oil
  5. custompurified by flash chromatography
  6. washThe flash column was eluted with a solvent gradient up to 65% EtOAc in Hexane

出典と根拠

ORDレコード
ord-6ecc2038f5634ecaabb807aa142c9e79
出典データセット
uspto-grants-2013_04
特許番号
US08410284B2

反応ノート

読み込み中…