Trifluoroacetic acid → N-[5-(6-benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-yl]-benzene-1,4-diamine

HRID 19606

反応式

HRID 19606 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15]2[N:20]3[N:21]=[CH:22][CH:23]=[C:19]3[CH:18]=[C:17]([C:24]3[CH:33]=[CH:32][C:31]4[C:26](=[CH:27][CH:28]=[C:29]([O:34][CH2:35][C:36]5[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=5)[CH:30]=4)[CH:25]=3)[N:16]=2)=[CH:10][CH:9]=1)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH2:35]([O:34][C:29]1[CH:30]=[C:31]2[C:26](=[CH:27][CH:28]=1)[CH:25]=[C:24]([C:17]1[N:16]=[C:15]([NH:14][C:11]3[CH:12]=[CH:13][C:8]([NH2:7])=[CH:9][CH:10]=3)[N:20]3[N:21]=[CH:22][CH:23]=[C:19]3[CH:18]=1)[CH:33]=[CH:32]2)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67319245{4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester2 回

生成物 1

HCID 67318736N-[5-(6-benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-yl]-benzene-1,4-diamine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of {4-[5-(6-benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester (compound C2)(450 mg), TFA (2 ml) and dichloromethane (10 ml) is stirred 4 h at ambient temperature. The reaction mixture is evaporated and coevaporated with toluene. The residue is partitioned between a aqueous saturated solution of sodium bicarbonate and ethyl acetate. After drying the organic phase is evaporated and the residue is dried in vacuum. A solid in quantitative yield is obtained.

後処理

  1. customThe reaction mixture is evaporated
  2. customThe residue is partitioned between a aqueous saturated solution of sodium bicarbonate and ethyl acetate
  3. customAfter drying the organic phase
  4. customis evaporated
  5. customthe residue is dried in vacuum
  6. customA solid in quantitative yield is obtained

出典と根拠

ORDレコード
ord-92581b61ab5249748f5b0032e571d119
出典データセット
uspto-grants-2010_06
特許番号
US07745446B2

関連ノート

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