Trifluoroacetic acid → (2S,4R)-4-Fluoro-N-(pyrazin-2-yl)pyrrolidine-2-carboxamide
反応式
[F:1][C@H:2]1[CH2:6][N:5](C(OC(C)(C)C)=O)[C@H:4]([C:14](=[O:22])[NH:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)[CH2:3]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C@H:2]1[CH2:6][NH:5][C@H:4]([C:14]([NH:15][C:16]2[CH:21]=[N:20][CH:19]=[CH:18][N:17]=2)=[O:22])[CH2:3]1参加物
4
実験手順
To a solution of (2S,4R)-tert-butyl 4-fluoro-2-(pyrazin-2-ylcarbamoyl)pyrrolidine-1-carboxylate 65A (4.1 g, 12.3 mmol) in CH2Cl2 (120 mL) was added TFA (10 mL). The reaction mixture was stirred at rt overnight. After concentration in vacuo, the residue was used for the next step without purification. LC/MS [M+H]+: 211; Ret time (Method F): 0.30 min.
後処理
- concentrationAfter concentration in vacuo
- customthe residue was used for the next step without purification
- custom0.30 min.
出典と根拠
- ORDレコード
- ord-c2169ffb5ae34a3ab17f1d73b3b440f2
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08415340B2
反応ノート
読み込み中…