Trifluoroacetic acid → (S)-Methyl 2,4,4-trimethylpyrrolidine-2-carboxylate
反応式
[CH3:1][C@@:2]1([C:16]([O:18][CH3:19])=[O:17])[CH2:6][C:5]([CH3:8])([CH3:7])[CH2:4][N:3]1C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][C@@:2]1([C:16]([O:18][CH3:19])=[O:17])[CH2:6][C:5]([CH3:7])([CH3:8])[CH2:4][NH:3]1参加物
4
実験手順
To a stirred solution of (S)-1-tert-butyl 2-methyl 2,4,4-trimethylpyrrolidine-1,2-dicarboxylate 106D in CH2Cl2 (60 ml) was added TFA (10 mL). The reaction mixture was stirred at room temperature overnight and concentrated. The residue was used for the next step without purification.
後処理
- concentrationconcentrated
- customThe residue was used for the next step without purification
出典と根拠
- ORDレコード
- ord-ea47e503766a446697f9f27244e5cca6
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08415340B2
反応ノート
読み込み中…